Four men from Halifax died in a two-vehicle crash on Highway 104 in Pictou County.
It happened around midnight near Priestville.
RCMP say it was a head-on collision between a car and an SUV in the eastbound lane of the divided highway.
Among the deceased include the 51-year old driver and sole occupant of the car, and three men in the SUV aged 51, 55 and 61.
A 51-year old passenger in the SUV is in hospital with life-threatening injuries.
Police say their investigation is on-going.
The section of highway was closed overnight into late this morning.